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KMID : 1140120120170010008
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Cancer Prevention Research
2012 Volume.17 No. 1 p.8 ~ p.14
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Anti-oxidative and Anti-mutagenic Effects of Saengshik
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Kim Dong-Ju
Kim Joong-Hark
Choi Su-Min
Hwang Sung-Ju
Hong Seong-Gil
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Abstract
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The objective of this study was to investigate of Saengshik which has anti-oxidant and anti-mutagenic activities. We investigate anti-oxidative of Saengshik was evaluated by DPPH radical scavenging, thiobarbituric acid-reacting substances (TBARS) inhibition rate, oxygen radical antioxidant capacity (ORAC) value and total anti-oxidant status (TAS). Anti-mutagenic effects of Saengshik through Ames test, which was used Salmonella typhimurium tester and it was treated with strain TA 100 acting mutagen (2-aminoanthracene) Anti-oxidant activities of Saengshik are increased in dose dependent manner. DPPH radical scavenging activity was 67.96% at 10 mg/ml of Saengshik treatment concentration as compared to 100% by pyrogallol as a reference. TBARS inhibition rate by Saengshik treatment was 62.59% at 10mg/ml. ORAC value and TAS by treatment of Saengshik were increased in dose dependent manner. The inhibitory effect of Saengshik on mutagenicity mediated by 2-aminoanthracenein were 82% in Salmonella Typhimurium TA 100. These results showed that Saengshik have an anti-oxidative activity and anti-mutagenic capacity.
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KEYWORD
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Saengshik, Anti-oxidant, Anti-mutagen
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